業績

尾仲宏康特任教授による以前の論文

2011年

  1. Tadashi Hatanaka, Hiroyasu Onaka, Extracellular production of recombinant enzymes by Streptomyces lividans. Current Trends in Microbiology 7: 53-59 (2011)
  2. 尾仲宏康、ミコール酸含有細菌との接触が誘発する放線菌の二次代謝
    バイオサイエンスとインダストリー 69(6): 476-480 (2011)
  3. 尾仲宏康、リボソームが作る抗生物質
    生物工学会誌 89(10): 616 (2011)
  4. S. Asamizu, Y. Shiro, Y. Igarashi, S. Nagano, H. Onaka*, Characterization and functional modification of StaC and RebC, which are involved in pyrrole oxidation of indolocarbazole biosynthesis. Biosci Biotechnol Biochem 75(11): 2184-93 (2011)
  5. H. Onaka*, Y. Mori, Y. Igarashi, T. Furumai, Mycolic acid-containing bacteria induce natural-product biosynthesis in Streptomyces species. Appl Environ Microbiol 77(2): 400-6 (2011)

2010年

  1. 尾仲宏康、永野真吾、インドール環転移酵素、VioEの反応機構ビオラセインに見られるトリッキーなインドール環転移反応、化学と生物 48(10): 660-662 (2010)
  2. Noguchi A, Kitamura T, Onaka H, Horinouchi S, Ohnishi Y. A copper-containing oxidase catalyzes C-nitrosation in nitrosobenzamide biosynthesis. Nat Chem Biol 6(9):641-643 (2010)
  3. Igarashi Y, Kim Y, In Y, Ishida T, Kan Y, Fujita T, Iwashita T, Tabata H, Onaka H, Furumai T. Alchivemycin A, a bioactive polycyclic polyketide with an unprecedented skeleton from Streptomyces sp. Org Lett 12(15): 3402-5 (2010)
  4. Igarashi Y, Shimasaki R, Miyanaga S, Oku N, Onaka H, Sakurai H, Saiki I, Kitani S, Nihira T, Wimonsiravude W, Panbangred W, Rakicidin D, an inhibitor of tumor cell invasion from marine-derived Streptomyces sp. J Antibiot (Tokyo) 63(9): 563-5. (2010)

2009年

  1. Miyanaga S, Sakurai H, Saiki I, Onaka H, Igarashi Y., Anti-invasive and anti-angiogenic activities of naturally occurring dibenzodiazepine BU-4664L and its derivatives. Anti-invasive and anti-angiogenic activities of naturally occurring dibenzodiazepine BU-4664L and its derivatives. Bioorg Med Chem Lett 20(3): 963-5. (2009)
  2. H. Onaka*, Biosynthesis of indolocarbazole and goadsporin, two different heterocyclic antibiotics produced by actinomycetes. Biosci Biotechnol Biochem 73(10): 2149-2155 (2009)
  3. Y. Wang, H. Chen, M. Makino, Y. Shiro, S. Nagano*, S. Asamizu, H. Onaka*, Sason Shaik*, Theoretical and Experimental Studies of the Conversion of Chromopyrrolic Acid to an Antitumor Derivative by Cytochrome P450 StaP: The Biological Role of Water Molecules. Journal of the American Chemical Society 131:6748-62 (2009)
  4. 尾仲宏康、インドロカルバゾール化合物の生合成に関与する新奇酵素、生物工学会誌 87(4), 194 (2009)
  5. S. Miyanaga, H. Sakurai, I. Saiki, H. Onaka, Y. Igarashi*, Synthesis and evaluation of myxochelin analogues as antimetastatic agents. Bioorganic & Medicinal Chemistry 17: 2724-2732 (2009)
  6. 尾仲宏康、微生物の複合培養法を用いた新規抗生物質製造法
    ケミカルエンジニヤリング 1月号 44-50 (2009)

2008年

  1. T. Hatanaka*, H. Onaka, J. Arima, M. Uraji, Y. Uesugi, H. Usuki, Y. Nishimoto, M. Iwabuchi, pTONA5: A hyperexpression vector in streptomycetes. Protein Expression and Purification 62: 244–248 (2008)
  2. Wang, Y. Hirao, H. Chen, H. Onaka, H. Nagano, S. Shaik, S., Electron Transfer Activation of Chromopyrrolic Acid by Cytochrome P450 En-Route to the Formation of an Antitumor Indolocarbazole Derivative - Theory Supports Experiment. J Am Chem Soc 130(23): 7170-7171 (2008)
  3. 尾仲宏康、城宜嗣、永野真吾、P450の電子引抜き反応による抗がん剤インドロカルバゾール骨組み構築
    バイオインダストリー 1月号 22-24 (2008)
  4. Satoshi Hirano, Shumpei Asamizu, Hiroyasu Onaka, Yoshitsugu Shiro, and Shingo Nagano,　Crystal structure of VioE, a key player in the construction of the molecular skeleton of violacein.
    Journal of Biological Chemistry 283(10):6459-66 (2008)

2007年

  1. Y. Hayashi, H. Onaka, N. Itoh, H. Seto, T. Dairi, Cloning of the Gene Cluster Responsible for Biosynthesis of KS-505a (longestin), a Unique Tetraterpenoid.
    Biosci Biotechnol Biochem 71(12):3072-81 (2007)
  2. 林篤志、嶋田貴志、尾仲宏康、古米保、富山湾深層水からのEnterococcus属乳酸菌の分離と諸性状の検討
    Japanese Journal of Acid Bacteria 18: 58-64 (2007)
  3. M. Makino, H. Sugimoto, Y. Shiro, S. Asamizu, H. Onaka, S. Nagano, Crystal structures and catalytic mechanism of cytochrome P450 StaP that produces the indolocarbazole skeleton.
    Proc Natl Acad Sci U S A 104: 11591-11596 (2007)
  4. S. Asamizu, Y. Kato, Y. Igarashi, H. Onaka, VioE, a prodeoxyviolacein synthase involved in violacein biosynthesis, is responsible for intramolecular indole rearrangement.
    Tetrahedron letters 48: 2923-2926 (2007)

2006年

  1. H. Onaka, Biosynthesis of heterocyclic antibiotics in actinomycetes and an approach to synthesize the natural compounds.
    Actinomycetologica 20: 62-71 (2006)
  2. S. Miyanaga, T. Obata, H. Onaka, T. Fujita, N. Saito, H. Sakurai, I. Saiki, T. Furumai, Y. Igarashi, Absolute configuration and antitumor activity of myxochelin A produced by Nonomuraea pusilla TP-A0861.
    J Antibiot (Tokyo) 59: 698-703 (2006)
  3. S. Asamizu, Y. Kato, Y. Igarashi, T. Furumai, H. Onaka, Direct formation of chromopyrrolic acid from indole-3-pyruvic acid by StaD, a novel hemoprotein in indolocarbazole biosynthesis
    Tetrahedron letters 47: 473-475 (2006)

2005年

  1. H. Onaka, M. Nakaho, K. Hayashi, Y. Igarashi, T. Furumai, Cloning and characterization of goadsporin biosynthetic gene cluster from Streptomyces sp. TP-A0584.
    Microbiology 151: 3923-3933 (2005)
  2. H. Onaka, S. Asamizu, Y. Igarashi, R. Yoshida, T. Furumai, Cytochrome P450 homolog is responsible for C–N bond formation between aglycone and deoxysugar in the staurosporine biosynthesis of Streptomyces sp. TP-A0274.
    Biosci Biotechnol Biochem 69: 1753-1759 (2005)
  3. Igarashi Y, In Y., Ishida T., Fujita T., Yamakawa T., Onaka H., Furumai T., Absolute configuration of TPU-0043, a pentaene macrolide from Streptomyces sp.
    J Antibiot (Tokyo) 58: 523-525 (2005)
  4. Igarashi Y, Miyanaga S, Onaka H, Takeshita M, Furumai T., Revision of the structure assigned to the antibiotic BU-4664L from Micromonopora.
    J Antibiot (Tokyo) 58: 350-352 (2005)
  5. Igarashi Y, Ootsu K, Onaka H, Fujita T, Uehara Y, Furumai T., Anicemycin, a new inhibitor of anchorage-independent growth of tumor cells from Streptomyces sp. TP-A0648.
    J Antibiot (Tokyo) 58:322-326 (2005)
  6. Ikeda Y, Nonaka H, Furumai T, Onaka H, Igarashi Y., Nocardimicins A, B, C, D, E, and F, siderophores with muscarinic M3 receptor inhibiting activity from Nocardia sp. TP-A0674.
    J Nat Prod 68: 1061-1065 (2005)
  7. 尾仲宏康、放線菌由来複素環抗生物質の生合成研究および新規物質創製への展開
    長瀬科学技術振興財団研究報告集 2004年度版 vol. 16, (2005) p.77-86

2004年

  1. 尾仲宏康、谷口真市、五十嵐康弘、古米保、Award for Excellence to authors publishing in Bioscience, Biotechnology, and Biochemistry. Lechevalieria aerocolonigenes ATCC39243のレベッカマイシン生合成遺伝子群の解析
    日本農芸化学会誌 vol.78, No.9, p48~49 (2004)
  2. H. Onaka, Characterization of the biosynthetic gene cluster of goadsporin which promotes secondary metabolism and sporulation in actinomycetes.
    Report of the Noda Institute for Scientific Research 48, 127-128 (2004)
  3. H. Onaka, Studies on goadsporin: mechanism of its action on the induction of secondary metabolism and sporulation in streptomycetes, and its application. The Waksman Foundation of Japan INC. Report of Researches in 2003 1-11 (2004)
  4. M. Shimizu, Y. Igarashi, T. Furumai, H. Onaka, and H. Kunoh, Identification of endophytic Streptomyces sp. R-5 and analysis of its antimicrobial metabolites.
    J Gen Plant Pathol 70: 66-68 (2004)

2003年

  1. H. Onaka, S. Taniguchi, Y. Igarashi and T. Furumai, pTOYAMAcos, pTYM18, and pTYM19, actinomycete-Escherichia coli integrating vectors for heterologous gene expression,
    The Journal of Antibiotics 56: 950-956 (2003)
  2. H. Minamiyama, M. Shimizu, H. Kunoh, T. Furumai, Y. Igarashi, H. Onaka and R. Yoshida, Multiplication of isolate R-5 of Streptomyces galbus on rhododendron leaves and its production of cell wall-degrading enzymes,
    J. Gen. Plant Pathol 69: 65-70 (2003)
  3. H. Onaka, S. Taniguchi, Y. Igarashi, and T. Furumai, Characterization of the biosynthetic gene cluster of rebecamycin from Lechevalieria aerocolonigenes ATCC 39243,
    Bioscience Biotechnology and Biochemistry 67: 127-138 (2003)
    BBB論文賞受賞論文

2002年

  1. H. Onaka, S. Taniguchi, Y. Igarashi, and T. Furumai, Cloning of the staurosporine biosynthetic gene cluster from Streptomyces sp. TP-A0274 and its heterologous expression in Streptomyces lividans,
    The Journal of Antibiotics 55: 1063-1071 (2002)
  2. T. Furumai, K. Eto, T. Sasaki, H. Onaka, N. Saito and Y. Igarashi, TPU-0037-A, B, C and D, novel lydicamycin congeners with anti-MRSA activity from Streptomyces platensis TP-A0598,
    The Journal of Antibiotics 55: 873-880 (2002)

2001年

  1. H. Onaka, H. Tabata, Y. Igarashi, Y. Sato and T. Furumai, Goadsporin, a chemical substance which promotes secondary metabolism and morphogenesis in streptomycetes. I. Purification and Characterization,
    The Journal of Antibiotics 54, 1036-1044, (2001)
  2. Y. Igarashi, Y. Kan, K. Fujii, T. Fujita, K. Harada, H. Naoki, H. Tabata, H. Onaka and T. Furumai, Goadsporin, a chemical substance which promotes secondary metabolism and morphogenesis in streoptomycetes. II. Structure determination,
    The Journal of Antibiotics 54, 1045-1053 (2001)
  3. M. Shimizu, T. Furumai, Y. Igarashi, H. Onaka, T, Nishimura, R. Yoshida and H. Kunoh, Association of induced desease resistance of Rhododendron seedlings with inoculation of Streptomyces sp. R-5 and treatment with actinomycin D and amphotericin B to the tissue-culture medium,
    The Journal of Antibiotics 54, 501-505 (2001)
  4. M. Shimizu, N. Fujita, Y. Nakagawa, T. Nishimura, T. Furumai, Y. Igarashi, H. Onaka, R. Yoshida, and H. Kunoh, Disease resistance of tissue-cultured seedlings of Rhododendron after treatment with Streptomyces sp. R-5,
    J Gen Plant Pathol 67, 325-332 (2001).

2000年

  1. Y. Igarashi, M. Ogawa, Y. Sato, N. Saito, R. Yoshida, H. Kunoh, H. Onaka and T. Furumai, Fistupyrone, a Novelinhibitor of the infection of chinese cabbage by Alternaria brassicicola, from Streptomyces sp. TP-A0569,
    The Journal of Antibiotics 53, 1117-1122 (2000)
  2. M. Shimizu, Y. Nakagawa, Y. Sato, T. Furumai, Y. Igarashi, H. Onaka, R. Yoshida and H. Kunoh, Studies on endophytic actinomycetes (I) Streptmyces sp. isolated from Rhododendron and its antifungal activity,
    Journal of General Plant Pathology 66, 360-366 (2000)
  3. S. Horinouchi, H. Onaka, H. Yamazaki, S. Kameyama and Y. Ohnishi, Isolation of DNA fragments bound by transcriptional factors, AdpA and ArpA, in the A-factor regulatory cascade,
    Actinomycetologica 14, 11-16 (2000)

1999年

  1. Y. Ohnishi, S. Kameyama, H. Onaka and S. Horinouchi, The A-factor regulatory cascade leading to streptomycin biosynthesis in Streptomyces griseus: Identification of a target gene of the A-factor receptor,
    Molecular Microbiology 34, 102-111 (1999)

1998年

  1. H. Onaka, T. Nakagawa and S. Horinouchi, Involvement of two receptor homologs in Streptomyces coelicolor A3(2) in the regulation of secondary metabolism and morphogenesis,
    Molecular Microbiology 28, 743-753 (1998)
  2. M. Sugiyama, H. Onaka, T. Nakagawa and S. Horinouchi, Site-directed mutagenesis of the A-factor receptor protein: Val-41 important for DNA-binding and Trp-119 important for ligand-binding,
    Gene 222, 133-144 (1998)

1997年

  1. H. Onaka and S. Horinouchi, DNA-binding activity of the A-factor receptor protein and its recognition DNA sequences,
    Molecular Microbiology 5, 991-1000 (1997)
  2. H. Onaka, M. Sugiyama and S. Horinouchi, A mutation at proline-115 in the A-factor receptor protein of Streptomyces griseus abolishes the DNA-binding ability but not the ligand-binding ability,
    Journal of Bacteriology 179, 2748-2752 (1997)

1995年

  1. H. Onaka, N. Ando, T. Nihira, Y. Yamada, T. Beppu and S. Horinouchi, Cloning and characterization of the A-factor receptor gene from Streptomyces griseus,
    Journal of Bacteriology 177, 6083- 6092 (1995)
  2. S. Horinouchi, T. Umeyama, H. Onaka, K. Ueda and T. Beppu, Streptomyces species as boundary microorganisms: Eucaryotic regulatory systems for secondary metabolism and morphological differentiation,
    Actinomycetologica 9, 244-253 (1995)

1994年

  1. K. Miyake, H. Onaka, S. Horinouchi and T. Beppu, Organization and nucleotide sequence of the secE-nusG region of Streptomyces griseus,
    Biochimica et Biophysica Acta 1217, 97-100 (1994)

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