A. A. Vinogradov, J. S. Chang, H. Onaka, Y. Goto, and H. Suga. Accurate Models of Substrate Preferences of Post-Translational Modification Enzymes from a Combination of mRNA Display and Deep Learning. ACS Central Science, (in press)
M. Kato, S. Asamizu, and H. Onaka*. Intimate relationships among soil bacteria: actinomycetes and mycolic acid-containing bacteria. Scientific Reports 12: 7222 (2022)
Y. Asai, T. Hiratsuka, M. Ueda, Y. Kawamura, S. Asamizu, H. Onaka, M. Arioka, S. Nishimura, M. Yoshida*. Differential Biosynthesis and Roles of Two Ferrichrome-Type Siderophores, ASP2397/AS2488053 and Ferricrocin, in Acremonium persicinum.ACS Chemical Biology, 17(1), 207-216 (2022)
A. Hikima, S. Asamizu, H. Onaka, H. Zhang, H. Tomoda*, N. Koyama. Kimidinomycin, a New Antibiotic against Mycobacterium avium Complex, Produced by Streptomyces sp. KKTA-0263. The Journal of Antibiotics, 75(2), 72-76 (2022)
N. Oku, S. Takemura, H. Onaka*, Y. Igarashi*. NMR characterization of streptogramin B and L-156,587, a non-synergistic pair of the streptogramin family antibiotic complexes produced inductively by a combined culture of Streptomyces albogriseolus and Tsukamurella pulmonis.MRC 60(2): 261-270 (2022)
T. Nagakubo, T. Yamamoto, S. Asamizu, M. Toyofuku, N. Nomura, H. Onaka*. Phage tail-like nanostructures affect microbial interactions between Streptomyces and fungi. Scientific Reports, 11(1), 20116 (2021)
Y. Jiang, T. Matsumoto, T. Kuranaga, S. Lu, W. Wang, H. Onaka, H. Kakeya, Longicatenamides A-D, Two Diastereomeric Pairs of Cyclic Hexapeptides Produced by Combined-culture of Streptomyces sp. KUSC_F05 and Tsukamurella pulmonis TP-B0596. The Journal of Antibiotics, 74, 307–316 (2021)
C. Pan, T. Kuranaga, X. Cao, T. Suzuki, N. Dohmae, N. Shinzato, H. Onaka, H. Kakeya, Amycolapeptins A and B, Cyclic Nonadepsipeptides Produced by Combined-culture of Amycolatopsis sp. and Tsukamurella pulmonis.The Journal of Organic Chemistry 86(2), 1843-1849 (2021)
Vinogradov AA*, Nagai E, Chang JS, Narumi K, Onaka H*, Goto Y*, Suga H*. Accurate Broadcasting of Substrate Fitness for Lactazole Biosynthetic Pathway from Reactivity-Profiling mRNA Display. Journal of the American Chemical Society, 142, 48, 20329–20334 (2020) doi: 10.1021/jacs.0c10374.
A. A. Vinogradov, M. Shimomura, N. Kano, Y. Goto, H. Onaka, and H. Suga.* Promiscuous enzymes cooperate at the substrate level en route to lacatzole A. Journal of the American Chemical Society, 142, 32, 13886–13897 (2020)
R. Kozakai, T. Ono, S. Hoshino, H. Takahashi, Y. Katsuyama, Y. Sugai, T. Ozaki, K. Teramoto, K.Teramoto, K. Tanaka, I. Abe, S. Asamizu, and H. Onaka*. Acyltransferase that catalyses the condensation of polyketide and peptide moieties of goadvionin hybrid lipopeptides. Nature Chemistry, 12: 869–877 (2020); doi: 10.1038/s41557-020-0508-2.
A. A. Vinogradov, M. Shimomura, Y. Goto, T. Ozaki, S. Asamizu, Y. Sugai, H. Suga*, H. Onaka*. Minimal lactazole scaffold for in vitro thiopeptide bioengineering. Nature Communications, 2020; 11: 2272. doi: 10.1038/s41467-020-16145-4
尾仲宏康*, 浅水俊平 物理的接触が介在する放線菌二次代謝誘導. Journal of Environmental Biotechnology(環境バイオテクノロジー学会誌)20: 13–22 (2020)
L. Vaario*, S. Asamizu, T. Sarjala, N. Matsushita, H. Onaka, Y. Xia, H. Kurokochi, S. Morinaga, J. Huang, S. Zhang, C. Lian. Bioactive properties of streptomyces may affect the dominance of Tricholoma matsutake in shiro. Symbiosis, 1-13 (2020)
Y Jiang, S Lu, G Hirai, T Kato, H Onaka, H Kakeya*. Enhancement of saccharothriolide production and discovery of a new metabolite, saccharothriolide C2, by combined-culture of Saccharothrix sp. and Tsukamurella pulmonis. Tetrahedron Letters, 60 (15), 1072-1074 (2019)
R. Sugiyama, T. Nakatani, S. Nishimura, K. Takenaka, T. Ozaki, S. Asamizu, H. Onaka, H. Kakeya*. Chemical Interactions of Cryptic Actinomycete Metabolite 5‐Alkyl‐1, 2, 3, 4‐tetrahydroquinolines through Aggregate Formation. Angewandte Chemie International Edition, 131 (38), 13620-13625 (2019)
Hoshino S, Onaka H, Abe I. Activation of silent biosynthetic pathways and discovery of novel secondary metabolites in actinomycetes by co-culture with mycolic acid-containing bacteria. Journal of Industrial Microbiology & Biotechnology 46(3-4): 363-374 (2019)
尾仲 宏康、丸山 潤一、浅水 俊平、黒岩 真弓、北本 勝ひこ、山田 雅人、五島 徹也、赤尾 健「富山県産大麦麦芽から分離した酵母菌株「とやま産まれの酵母」の清酒醸造特性、Characterization of a wild Sake-brewing yeast isolated from barley malt in Toyama」日本醸造協会誌、114(3): 1-9 (2019)
Ozaki T, Sugiyama R, Shimomura M, Nishimura S, Asamizu S, Katsuyama Y, Kakeya H, Onaka H*. Identification of the common biosynthetic gene cluster for both antimicrobial streptoaminals and antifungal 5-alkyl-1,2,3,4-tetrahydroquinolines. Org Biomol Chem. in press (2019) doi: 10.1039/c8ob02846j
Hoshino S, Onaka H, Abe I. Activation of silent biosynthetic pathways and discovery of novel secondary metabolites in actinomycetes by co-culture with mycolic acid-containing bacteria. J Ind Microbiol Biotechnol. in press (2018) doi: 10.1007/s10295-018-2100-y
Hoshino S, Ozeki M, Awakawa T, Morita H, Onaka H, Abe I. Catenulobactins A and B, Heterocyclic Peptides from Culturing Catenuloplanes sp. with a Mycolic Acid-Containing Bacterium. J Nat Prod. 81(9): 2106-2110 (2018) doi: 10.1021/acs.jnatprod.8b00261
Hagihara R, Katsuyama Y, Sugai Y, Onaka H, Ohnishi Y. Novel desferrioxamine derivatives synthesized using the secondary metabolism-specific nitrous acid biosynthetic pathway in Streptomyces davawensis. J Antibiot (Tokyo). 71(11): 911-919 (2018) doi: 10.1038/s41429-018-0088-1.
Hoshino S, Ozeki M, Wong CP, Zhang H, Hayashi F, Awakawa T, Morita H, Onaka H, Abe I. Mirilactams C-E, Novel Polycyclic Macrolactams Isolated from Combined-Culture of Actinosynnema mirum NBRC 14064 and Mycolic Acid-Containing Bacterium. Chem Pharm Bull (Tokyo). 66(6): 660-667 (2018) doi: 10.1248/cpb.c18-00143.
Hoshino S, Wong CP, Ozeki M, Zhang H, Hayashi F, Awakawa T, Asamizu S, Onaka H, Abe I. Umezawamides, new bioactive polycyclic tetramate macrolactams isolated from a combined-culture of Umezawaea sp. and mycolic acid-containing bacterium. J Antibiot (Tokyo). 71(7): 653-657 (2018) doi: 10.1038/s41429-018-0040-4.
Hoshino, S., Okada, M., Awakawa, T., Asamizu, S., Onaka, H., Abe, I*. Mycolic Acid Containing Bacterium Stimulates Tandem Cyclization of Polyene Macrolactam in a Lake Sediment Derived Rare Actinomycete. Org Lett 19, 4992-4995 (2017) doi:10.1021/acs.orglett.7b02508
Onaka, H*. Novel antibiotic screening methods to awaken silent or cryptic secondary metabolic pathways in actinomycetes. J Antibiot (Tokyo) 70, 865-870 (2017) doi:10.1038/ja.2017.51
T. Ozaki, K. Yamashita, Y. Goto, M. Shimomura, S. Hayashi, S. Asamizu, Y. Sugai, H. Ikeda, H. Suga*, and H. Onaka*. Dissection of goadsporin biosynthesis by in vitro reconstitution leading to designer analogs expressed in vivo. Nature communications 8, 14207 (2017) doi:10.1038/ncomms14207
Sugiyama R, Nishimura S, Ozaki T, Asamizu S, Onaka H, Kakeya H. Discovery and Total Synthesis of Streptoaminals: Antimicrobial [5,5]-Spirohemiaminals from the Combined-Culture of Streptomyces nigrescens and Tsukamurella pulmonis.Angew Chem Int Ed Engl.55(35): 10278–10282 (2016) doi: 10.1002/anie.201604126.
Du D, Katsuyama Y, Onaka H, Fujie M, Satoh N, Shin-Ya K, Ohnishi Y. Production of a Novel Amide-Containing Polyene by Activating a Cryptic Biosynthetic Gene Cluster in Streptomyces sp. MSC090213JE08. Chembiochem. 17(15) :1464-71. doi: 10.1002/cbic.201600167.
尾仲宏康、複合培養による放線菌抗生物質生産の覚醒 Combined-culture: the new method for secondary metabolism activation in actinomycetes. バイオインダストリー 3月号 33: 4-10 (2016)
Ozaki T, Kurokawa Y, Hayashi S, Oku N, Asamizu S, Igarashi Y, Onaka H. Insights into the biosynthesis of dehydroalanines in goadsporin. ChemBioChem 2015 Dec 2. doi: 10.1002/cbic.201500541.
Hoshino S, Okada M, Wakimoto T, Zhang H, Hayashi F, Onaka H, Abe I. Niizalactams A-C, Multicyclic Macrolactams Isolated from Combined Culture of Streptomyces with Mycolic Acid-Containing Bacterium. J Nat Prod 2015 Dec 1. in press
Asamizu S,Ozaki T, Teramoto K, Satoh K, Onaka H. Killing of Mycolic Acid-Containing Bacteria Aborted Induction of Antibiotic Production by Streptomyces in Combined-Culture. PLoS One 2015 Nov 6;10(11):e0142372. doi: 10.1371/journal.pone.0142372.
Hoshino S, Wakimoto T, Onaka H, Abe I., Chojalactones A-C, Cytotoxic Butanolides Isolated from Streptomyces sp. Cultivated with Mycolic Acid Containing Bacterium. Org Lett 2015 Mar 20;17(6):1501-4. doi: 10.1021/acs.orglett.5b00385.
Sugiyama R, Nishimura S, Ozaki T, Asamizu S, Onaka H, Kakeya H. 5-Alkyl-1,2,3,4-tetrahydroquinolines, New Membrane-Interacting Lipophilic Metabolites Produced by Combined Culture of Streptomyces nigrescens and Tsukamurella pulmonis. Org Lett 2015 Apr 17;17(8):1918-21. doi: 10.1021/acs.orglett.5b00607.
H. Onaka, T. Ozaki, Y. Mori, M. Izawa, S. Hayashi, and S. Asamizu. Mycolic acid-containing bacteria activate heterologous secondary metabolite expression in Streptomyces lividans. J Antibiot (Tokyo) 2015 Apr 1. doi: 10.1038/ja.2015.31.
Hoshino S, Zhang L, Awakawa T, Wakimoto T, Onaka H, Abe I. Arcyriaflavin E, a new cytotoxic indolocarbazole alkaloid isolated by combined-culture of mycolic acid-containing bacteria and Streptomyces cinnamoneus NBRC 13823. J Antibiot (Tokyo) 2014 Oct 22. doi: 10.1038/ja.2014.147.
K.Haginaka, S. Asamizu,T. Ozaki, Y. Igarashi, T. Furumai, and H. Onaka*. Genetic approaches to generate hyper-producing strains of goadsporin: the relationships between productivity and gene duplication in secondary metabolite biosynthesis. Biosci Biotechnol Biochem 78(3): 394-399 (2014)
R. Uchida, M. Nakai, S. Ohte, H. Onaka, T. Katagiri, and H. Tomoda*. 5-Prenyltryptophol, a new inhibitor of bone morphogenetic protein-induced alkaline phosphatase expression in myoblasts, produced by Streptomyces colinus subsp. albescens HEK608. J Antibiot (Tokyo) 2014 May 14. doi: 10.1038/ja.2014.44.
S. Hayashi,T. Ozaki,S. Asamizu, H. Ikeda, S. Ōmura, N. Oku, Y. Igarashi, H. Tomoda, and H. Onaka*. Genome mining reveals a minimum gene set for the biosynthesis of 32-membered macrocyclic thiopeptides lactazoles. Chem Biol 21(5): 679-88 (2014)
Y. Kim, Y. In, T. Ishida, H. Onaka, and Y. Igarashi*. Biosynthetic origin of alchivemycin A, a new polyketide from Streptomyces and absolute configuration of alchivemycin B. Org Lett 15(14): 3514-3517 (2013)
M. Kameya, H. Onaka, and Y. Asano*. Selective tryptophan determination using tryptophan oxidases involved in bis-indole antibiotic biosynthesis., Anal Biochem 438(2): 124-132 (2013)
N. Koyama, M. Yotsumoto, H. Onaka. and H. Tomoda*. New structural scaffold 14-membered macrocyclic lactone ring for selective inhibitors of cell wall peptidoglycan biosynthesis in Staphylococcus aureus., J Antibiot (Tokyo) 66(5): 303-304 (2013)
Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, Camarero JA, Campopiano DJ, Challis GL, Clardy J, Cotter PD, Craik DJ, Dawson M, Dittmann E, Donadio S, Dorrestein PC, Entian KD, Fischbach MA, Garavelli JS, Göransson U, Gruber CW, Haft DH, Hemscheidt TK, Hertweck C, Hill C, Horswill AR, Jaspars M, Kelly WL, Klinman JP, Kuipers OP, Link AJ, Liu W, Marahiel MA, Mitchell DA, Moll GN, Moore BS, Müller R, Nair SK, Nes IF, Norris GE, Olivera BM, Onaka H, Patchett ML, Piel J, Reaney MJ, Rebuffat S, Ross RP, Sahl HG, Schmidt EW, Selsted ME, Severinov K, Shen B, Sivonen K, Smith L, Stein T, Süssmuth RD, Tagg JR, Tang GL, Truman AW, Vederas JC, Walsh CT, Walton JD, Wenzel SC, Willey JM, and van der Donk WA*. Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Nat Prod Rep 30(1): 108-160 (2012)
S. Asamizu, S. Hirano, H. Onaka*, H. Koshino, Y. Shiro, and S. Nagano*. Coupling Reaction of Indolepyruvic Acid in the Presence of StaD and Its Product: Implications for Biosynthesis of Indolocarbazole and Violacein. ChemBioChem 13(17): 2495-2500 (2012)
K. Sakai, N. Koyama, T. Fukuda, Y. Mori, H. Onaka, and H. Tomoda*. Search method for inhibitors of Staphyloxanthin production by methicillin-resistant Staphylococcus aureus.Biol Pharm Bull 35(1): 48-53 (2012)
Hiroyasu Onaka, “Short introduction of Onaka lab” 日本オランダ2国間JSPSセミナー、2022/3/3、高知県高知市(オンライン開催)
Shumpei Asamizu, “Bacterial interaction among actinomycetes and mycolic acid-containing bacteria” 日本オランダ2国間JSPSセミナー、2022/3/3、高知県高知市(オンライン開催)
LEI Yukun, “Investigation of the mechanism of induced undecylprodigiosin (RED) production during combined-culture of Streptomyces coelicolor and Tsukamurella pulmonis” 日本オランダ2国間JSPSセミナー、2022/3/3、高知県高知市(オンライン開催)
Shinta Ijichi, “Heterologous production of lactazole-like thiopeptides” 日本オランダ2国間JSPSセミナー、2022/3/3、高知県高知市(オンライン開催)
Emiko Nagai, “Detection of new antibiotics targeting signal recognition particle (SRP).” 日本オランダ2国間JSPSセミナー、2022/3/3、高知県高知市(オンライン開催)
Sachiko Kawano, “Mechanism of Action of Goadsporin” 日本オランダ2国間JSPSセミナー、2022/3/3、高知県高知市(オンライン開催)
Hansem Jo, “Isolation and Identification of Novel Lipolanthine.” 日本オランダ2国間JSPSセミナー、2022/3/3、高知県高知市(オンライン開催)
Manami Kato, “Three bacterial interaction - hyphae branching of Streptomyces induced by phenolic compound” 日本オランダ2国間JSPSセミナー、2022/3/3、高知県高知市(オンライン開催)
H. Onaka. “GNAT superfamily enzyme plays a key role in the biosynthesis of polyketide/peptide hybrid lipopeptides”, 1st Japan-Germany-Switzerland Workshop for Enzyme Technology and Bioprocess Development, Tateyama Kokusai Hotel, Toyama, Japan 2019/9/11
H. Onaka. “Combined-culture: co-culture with MACB induced potential secondary metabolism in actinomycetes”, Guest lecture of “The Role of Microbiome and Nutrition in Health and Disease” at Dept. of Pharmacology and Therapy, and Dept. of Microbiology, and Master of Biomedical Science in Gadjah Mada University, Yogyakarta, Indonesia 2019/9/3
Hiroyasu Onaka “Introduction” The 4th A3 Foresight Symposium on “Chemical & Synthetic Biology of Natural Products”, Shanghai Jiao Tong Unversity, Shanghai, 2019/7/6
Shumpei Asamizu, Hiroyasu Onaka “Intergeneric cell-cell contact dependent conversion of bioactive natural products in combined-culture between Streptomyces sp. HEK616 and Tsukamurella pulmonis” The 4th A3 Foresight Symposium on “Chemical & Synthetic Biology of Natural Products”, Shanghai Jiao Tong Unversity, Shanghai, 2019/7/6
Manami Kato, Shumpei Asamizu, Hiroyasu Onaka “Interrogating the relationship between filamentous actinomycetes and mycolic acid-containing bacteria in ecosystem” The 4th A3 Foresight Symposium on “Chemical & Synthetic Biology of Natural Products”, Shanghai Jiao Tong Unversity, Shanghai, 2019/7/6
Masashi Kida, Shumpei Asamizu, Hiroyasu Onaka “Toward understanding the mechanism of intergeneric cell-cell contact induced activation of secondary metabolism using Streptomyces coelicolor and Tsukamurella pulmonis as model system” The 4th A3 Foresight Symposium on “Chemical & Synthetic Biology of Natural Products”, Shanghai Jiao Tong Unversity, Shanghai, 2019/7/6
Ryosuke Kozakai, Shumpei Asamizu, Hiroyasu Onaka “Enzymatic condensation of RiPP and very long chain fatty acid to synthesize unprecedented lipopeptide” The 4th A3 Foresight Symposium on “Chemical & Synthetic Biology of Natural Products”, Shanghai Jiao Tong Unversity, Shanghai, 2019/7/6
Sachiko Kawano, Shumpei Asamizu, Hiroyasu Onaka “Toward understanding the mechanism of goadsporin induced activation of secondary metabolism” The 4th A3 Foresight Symposium on “Chemical & Synthetic Biology of Natural Products”, Shanghai Jiao Tong Unversity, Shanghai, 2019/7/6
Hiroyasu Onaka “Combined-culture: co-culture with MACB induced potential secondary metabolism in actinomycetes”, ISCE 2019 Annual Meeting, Georgia Tech Hotel & Conference Center, Atlanta, USA, 2019/6/4
Hiroyasu Onaka “Combined-culture: Potential secondary metabolism is promoted by co-culture with mycolic acid containing bacteria”, 2nd China-Japan Joint Symposium on Natural Product Biosynthesis, Jinan University, Guangzhou, China, 2019/1/14-15
Shumpei Asamizu, Hiroyasu Onaka, “Combined-culture to activating the production of secondary metabolites in Streptomyces species”, 2nd China-Japan Joint Symposium on Natural Product Biosynthesis, Jinan University, Guangzhou, China, 2019/1/14-15
尾仲宏康「Characterization of post-translational modification enzymes in thiopeptide biosynthesis and their application to drug screening」、Novozymes Japan研究ファンド成果発表会、UDXカンファレンス、東京都台東区、2018/11/2
Hiroyasu Onaka “Combined-culture: potential secondary metabolism is promoted by co-culture with mycolic acid containing bacteria” The Japanese-German Symposium, the University of Bonn, Bonn, Germany, 2018/9/6-7
Hiroyasu Onaka “In vitro reconstitution of RiPPs biosynthesis coupled by in vitro translation and post-translation modifications” 3rd Europian Conference on Natural Products, DECHEMA, Frankfurt am Main, Germany, 2018/9/3
Shotaro Hoshino, Takayoshi Awakawa, Hiroyasu Onaka, Ikuro Abe “Activation of silent biosynthetic genes of rare-actinomycetes by combined-culture with mycolic acid-containing bacterium” 2018 ASP Annual Meeting, Hilton Lexington/Downtown, Lexington, Kentucky, United States, 2018/7/23
Shumpei Asamizu “Toward the molecular mechanism of mycolic acid-containing bacteria induced actinomycetes specialized metabolism”, The 3rd A3 Foresight Symposium on Chemical & Synthetic Biology of Natural Products, Hotel North City, Sapporo, 2018/7/9-12
Manami Kato, Shumpei Asamizu, Kazuya Teramoto, Hiroyasu Onaka “Interaction between actinomycetes and mycolic acid-containing bacteria co-isolated from Hegura island soil”,The 3rd A3 Foresight Symposium on Chemical & Synthetic Biology of Natural Products, Hotel North City, Sapporo, 2018/7/9-12
Hiroyasu Onaka “RiPPs biosynthesis by in vitro reconstitution system”, The 3rd A3 Foresight Symposium on Chemical & Synthetic Biology of Natural Products, Hotel North City, Sapporo, 2018/7/9-12
Abrory Agus Chaya Pramana, Sungjin Kawai, Manami Kato, Shumpei Asamizu, Yoshinori Sugai, Hiroaki Suzuki, Yoshichika Arakawa, Hiroyasu Onaka “Discovery of a new antibiotic-siderophore hybrid compound from combined-culture of Streptomyces sp. HOK021 and Tsukamurella pulmonis.”、2018年度日本農芸化学会、愛知県名古屋市、名城大学、2018/3/15-18
Shotaro Hoshino, Takayoshi Awakawa, Hiroyasu Onaka, Ikuro Abe “Discovery of Novel Antibiotics from Rare-Actinomycetes Using Combined-Culture Strategy”, Natural Product Discovery and Development in the Genomic Era, Clearwater Beach, Florida, United States, 2018/1/21-24
H. Onaka “In vitro reconstitution of RiPPs biosynthesis by translational-coupled post-translational modification”, ASP meeting, Portland, OR, USA, 2017/6/31
H. Onaka “In vitro reconstitution of RiPPs biosynthesis by translational-coupled post-translational modification”, 9th US-JAPAN seminar on the biosynthesis of natural products, UCLA Lake Arrowhead Conference center, CA, USA, 2017/5/30
Shumpei Asamizu, Yoshinori Sugai, Hiroyasu Onaka “Trascriptomic responses of Streptomyces coelicolor A3(2) in Combined-culture environment with Tsukamurella pulmonis TP-B0596” ISBA2017, Jeju Korea, May 24, 2017
H. Onaka “Dissection of Goadsporin Biosynthesis by in vitro Reconstitution Leading to Designer Analogs Expressed in vivo”, 18th International Symposium on the Biology of Actinomycetes Workshop 1-1: A3 Foresight Network on Natural Products, International Convention Center JEJU, Korea, 2017/5/24
Shotaro Hoshino, Masahiro Okada, Hiroyasu Onaka, Ikuro Abe “Application of Combined Culture Method to Rare Actinomycetes” 18th International Symposium on the Biology of Actinomycetes, International Convention Center JEJU, Korea, 2017/5/24
Akira Kanada, Taro Ozaki, Yoshinori Sugai, Shumpei Asamizu, Toshiya Senda, and Hiroyasu Onaka, “Analysis of interaction between secondary metabolisms inducing peptide goadsporin and Ffh.”, 18th International Symposium on the Biology of Actinomycetes, International Convention Center JEJU, Korea, 2017/5/24
Yoshinori Sugai, Shumpei Asamizu, and Hiroyasu Onaka, “Biosynthetic Studies on the Class III Lantipeptide Synthetase Found in the Goadsporin Producing Strain Streptomyces sp. TP-A0584.”, 18th International Symposium on the Biology of Actinomycetes, International Convention Center JEJU, Korea, 2017/5/24
Akira Kanada, Taro Ozaki, Yoshinori Sugai, Shumpei Asamizu, Toshiya Senda, Hiroyasu Onaka, “Analysis of interaction between secondary metabolisms inducing peptide goadsporin and Ffh”, A3 Foresight Network on Natural Products, Grabel Hotel, Korea, 2017/5/23
Abrory Agus Cahya Pramana, Shumpei Asamizu, Yoshinori Sugai, Hiroyasu Onaka, “Analysis of intergeneric bacteria induced specialized metabolites with antibiosis from soil isolated actinomycetes.”, A3 Foresight Network on Natural Products, International Convention Center JEJU, Korea, 2017/5/24
Y. Sugai “Mode of action by goadsporin, the inducer of secondary metabolism and morphogenesis in actinomycetes” The 1st A3 Foresight Symposium on “Chemical & Synthetic Biology of Natural Products”, Shanghai Jiao Tong Unversity, Shanghai, 2016/8/23
S. Asamizu “Secondary metabolite induction by mycolic acid-containing bacteria in Streptomyces” The 1st A3 Foresight Symposium on “Chemical & Synthetic Biology of Natural Products”, Shanghai Jiao Tong Unversity, Shanghai, 2016/8/23
H. Onaka “Secondary metabolism activation in actinomycetes by chemical or physical communication” The 1st A3 Foresight Symposium on “Chemical & Synthetic Biology of Natural Products”, Shanghai Jiao Tong Unversity, Shanghai, 2016/8/22
H. Onaka & S. Asamizu, “Combined-culture: the novel co-culture method for secondary metabolism activation in actinomycetes”, The 5th International Conference on Cofactors (ICC-05) and Active Enzyme Molecule 2016 (AEM 2016) , Unazuki, Toyama, Japan, 2016/9/4-8
T. Ozaki, K. Yamashita, S. Hayashi, Y. Goto, H. Suga, S. Asamizu & H. Onaka, “In vivo and In vitro reconstitution of dehydroalanine biosynthesis in goadsporin, a linear azole containing RiPP”, SIMB annual meeting, Sheraton New Orleans, New Orleans, LA, 2016/7/24-28
S. Hoshino, L. Zhang, T. Awakawa, T. Wakimoto, H. Onaka and I. Abe, “Mycolic acid-containing bacteria induce the production of novel secondary metabolites in Streptomyces strains”, American Society of Pharmacognosy 2015 Annual Meeting, Copper Mountain Resort and Conference Center, Copper Mountain, Colorado, 2016/7/26
Morito Shimomura, Taro Ozaki, Yoshinori Sugai, Shumpei Asamizu, Kona Yamashita, Yuki Goto, Hiroaki Suga and Hiroyasu Onaka, “In vitro reconstitution of Lactazole biosynthetic pathway coupled with cell-free translation system” 2016年度生合成若手勉強会、東京大学、東京都文京区、2016/7/23
Hiroyasu Onaka, "Combined-culture: the new method for secondary metabolism activation in actinomycetes", Pacifichem 2015, Honolulu, Hawaii, USA, 2015/12/19
Taro Ozaki, Shumpei Asamizu, Hiroyasu Onaka, “Characterization of the mechanism for the goadsporin self-resistance”, Natural Product Discovery and Development in the Post Genomic Era, SanDiego, 2015/1/11-14
Shumpei Asamizu, Taro Ozaki, Hiroyasu Onaka, “Secondary metabolites induction by mycolic acid-containing bacteria in Streptomyces”, Natural Product Discovery and Development in the Post Genomic Era, SanDiego, 2015/1/11-14
Ryosuke Sugiyama, Shinichi Nishimura, Taro Ozaki, Hiroyasu Onaka and Hideaki Kakeya, “5-Alkyl-1,2,3,4-tetrahydroquinolines, membrane-interacting lipophilic metabolites, found in combined-culture of Streptomyces sp. HEK616 and Tsukamurella pulmonis”, Natural Product Discovery and Development in the Post Genomic Era, SanDiego, 2015/1/11-14
Shohei Hayashi, Taro Ozaki, Shumpei Asamizu, Hiroyasu Onaka, “Genome mining reveals a minimum gene set for the biosynthesis of lactazoles, novel 32-membered macrocyclic thiopeptides”, Natural Product Discovery and Development in the Post Genomic Era, SanDiego, 2015/1/11-14
Kazuma Ebata, Kona Yamashita, Taro Ozaki, Shumpei Asamizu, Yuki Goto, Hiroaki Suga, and Hiroyasu Onaka, “Characterization of a cryptic lanthipeptide synthetase by cell-free transcription system”, Active Enzyme Molecule 2014 in Toyama, Toyama, 2014/12/17-19
Hiroyasu Onaka, Shumpei Asamizu, Taro Ozaki, "Combined induction: a fermentation method for heterologous secondary metabolite production in Streptomyces", 17th International symposium on biology of actinomycetes, Kusadasi, Turkey, 2014/10/8-12
Taro Ozaki, Makoto Nishiyama, and Tomohisa Kuzuyama, "Novel tryptophan metabolism in actinomycetes", US-Japan Seminar on the Biosynthesis of Natural Products for Young Researcher, Tokyo Institute of Technology, Kanagawa, 2014/3/2-3
Shumpei Asamizu, "Intergenetic interaction induces secondary metabolism in Strepotmyces", US-Japan Seminar on the Biosynthesis of Natural Products for Young Researcher, Tokyo Institute of Technology, Kanagawa, 2014/3/2-3
Hiroyasu Onaka, "Combined induction: a fermentation method for heterologous secondary metabolite production in Streptomyces.", 1st European Conference on Natural Products: Research and Application (ECNP), Frunkfurt, Germany, 2013/9/22-25
Hiroyasu Onaka, "Combined culture" and "combined induction": Activation of sleeping enzymatic genes involved in the secondary metabolism of actinomycetes", 17th German-Japanese Workshop on Enzyme Technology, Technical University, Hamburg-Harburg, Hamburg, 2013/7/27
Hiroyasu Onaka, Yukiko Mori, Masumi Izawa, Shohei Hayashi, "Combined induction: effective fermentation procedure for heterologous secondary metabolite production in actinomycetes", 12th International Symposium on the Genetics of Industrial Microorganisms (GIM), the Cancun Convention Center, Cancun, 2013/6/25